Dermatology 2013

Notes: Rabasseda, X

eng

Congresses

Barcelona, Spain : 1998

2013/11/06 06:00

Drugs Today (Barc). 2013 Oct;49(10):667-77. doi: 10.1358/dot.2013.49.10.2076505.

URL: http://www.ncbi.nlm.nih.gov/pubmed/24191258

Author Address: Thomson Reuters, Barcelona, Spain. xavier.rabasseda@thomsonreuters.com.

 

 

Reference Type:  Journal Article

Record Number: 4508Author: Rakers, S., Niklasson, L., Steinhagen, D., Kruse, C., Schauber, J., Sundell, K. and Paus, R.

Year: 2013

Title: Antimicrobial peptides (AMPs) from fish epidermis: perspectives for investigative dermatology

Journal: J Invest Dermatol

Volume: 133

Issue: 5

Pages: 1140-9

Date: May

Short Title: Antimicrobial peptides (AMPs) from fish epidermis: perspectives for investigative dermatology

Alternate Journal: The Journal of investigative dermatology

ISSN: 1523-1747 (Electronic)

0022-202X (Linking)

DOI: 10.1038/jid.2012.503

Accession Number: 23407389

Keywords: Animals

Antimicrobial Cationic Peptides/*metabolism

Epidermis/immunology/*metabolism

Fishes/immunology/*metabolism

Humans

Immunity, Innate/physiology

Models, Animal

Mucus/immunology/metabolism

Abstract: Mammalian and fish skin share protective activities against environments that are rich in infectious agents. Fish epidermis is endowed with an extrinsic barrier consisting of a mucus layer and antimicrobial peptides (AMPs). These operate together as a protective chemical shield. As these AMPs are evolutionarily well preserved and also found in higher vertebrate skin (including human epidermis), fish skin offers a unique opportunity to study the origins of innate antimicrobial defense systems. Furthermore, the broad spectrum of fish mucus antimicrobial activities renders piscine AMPs interesting to investigative dermatology, as these may become exploitable for various indications in clinical dermatology. Therefore, this article aims at casting light on fish mucus, the evolutionary relationship between human and fish AMPs, and the latter’s antibacterial, antifungal, and even antiviral activities. Moreover, we develop dermatological lessons from, and sketch potential future clinical applications of, fish mucus and piscine AMPs.

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