November 8, 2014
Notes: Bilgili, S G
Ozkol, H U
Karadag, A S
Hum Exp Toxicol. 2014 Feb;33(2):214-21. doi: 10.1177/0960327113494904. Epub 2013 Jul 8.
Author Address: 1Department of Dermatology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
Reference Type: Journal Article
Record Number: 4298Author: Blumenberg, M.
Title: Skinomics: past, present and future for diagnostic microarray studies in dermatology
Journal: Expert Rev Mol Diagn
Short Title: Skinomics: past, present and future for diagnostic microarray studies in dermatology
Alternate Journal: Expert review of molecular diagnostics
ISSN: 1744-8352 (Electronic)
Accession Number: 24151852
Gene Expression Profiling
*Oligonucleotide Array Sequence Analysis
Tumor Markers, Biological/genetics/*metabolism
Abstract: Easily accessible, skin was among the first targets analyzed using ‘omics’ and dermatology embraced the approaches very early. Microarrays have been used to define disease markers, identify transcriptional changes and even trace the course of treatment. Melanoma and psoriasis have been explored using microarrays. Particularly noteworthy is the multinational mapping of psoriasis susceptibility loci. The transcriptional changes in psoriasis have been identified using hundreds of biopsies. Epidermal keratinocytes have been studied because they respond to UV light, infections, inflammatory and immunomodulating cytokines, toxins and so on. Epidermal differentiation genes are being characterized and are expressed in human epidermal stem cells. Exciting discoveries defining human skin microbiomes have opened a new field of research with great medical potential. Specific to dermatology, the non-invasive skin sampling for microarray studies, using tape stripping, has been developed; it promises to advance dermatology toward ‘omics’ techniques directly applicable to the personalized medicine of the future.