Dermatology 2013

Combined Modality Therapy

Cost-Benefit Analysis

Drug Substitution

*Evidence-Based Medicine

Female

Humans

Immunosuppressive Agents/therapeutic use

Male

Meta-Analysis as Topic

Multicenter Studies as Topic

Photochemotherapy

Pregnancy

Pregnancy Complications/drug therapy

Psoriasis/*drug therapy

Severity of Illness Index

Sex Factors

Spain

Treatment Failure

Treatment Outcome

Abstract: Biologic therapy is a well-established strategy for managing moderate and severe psoriasis. Nevertheless, the high cost of such therapy, the relatively short span of clinical experience with biologics, and the abundance of literature now available on these agents have made evidence-based and consensus-based clinical guidelines necessary. The ideal goal of psoriasis treatment is to achieve complete or nearly complete clearing of lesions and to maintain it over time. Failing that ideal, the goal would be to reduce involvement to localized lesions that can be controlled with topical therapy. Although current evidence allows us to directly or indirectly compare the efficacy or risk of primary or secondary failure of available biologics based on objective outcomes, clinical trial findings cannot be directly translated to routine practice. As a result, the prescribing physician must tailor the treatment regimen to the individual patient. This update of the clinical practice guidelines issued by the Spanish Academy of Dermatology and Venereology (AEDV) on biologic therapy for psoriasis incorporates information from the most recent publications on this topic.

Notes: Puig, L

Carrascosa, J M

Carretero, G

de la Cueva, P

Lafuente-Urrez, R F

Belinchon, I

Sanchez-Regana, M

Garcia-Bustinduy, M

Ribera, M

Alsina, M

Ferrandiz, C

Fonseca, E

Garcia-Patos, V

Herrera, E

Lopez-Estebaranz, J L

Marron, S E

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