Cardiology 2013 (Full reference info)

Reference Type: Journal Article
Record Number: 429Author: De Backer, D.
Year: 2013
Title: Year in review 2012: Critical Care – cardiology
Journal: Crit Care
Volume: 17
Issue: 6
Pages: 247
Date: Nov 22
Short Title: Year in review 2012: Critical Care – cardiology
Alternate Journal: Critical care
ISSN: 1466-609X (Electronic)
1364-8535 (Linking)
DOI: 10.1186/cc13127
Accession Number: 24267398
Abstract: In this review I discuss key research papers in cardiology and intensive care published in Critical Care during 2012 with related studies published in other journals quoted whenever appropriate. These studies are grouped into the following categories: cardiovascular therapies, mechanical therapies, pathophysiologic mechanisms, hemodynamic monitoring, ultrasound in respiratory failure, microcirculation, and miscellaneous.
Notes: De Backer, Daniel
ENG
London, England
2013/11/26 06:00
Crit Care. 2013 Nov 22;17(6):247.
URL: http://www.ncbi.nlm.nih.gov/pubmed/24267398
Author Address: Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, B-1070, Brussels, Belgium. ddebacke@ulb.ac.be.

Reference Type: Journal Article
Record Number: 460Author: de Boer, S. P., van Leeuwen, M. A., Cheng, J. M., Oemrawsingh, R. M., van Geuns, R. J., Serruys, P. W., Boersma, E. and Lenzen, M. J.
Year: 2013
Title: Trial participation as a determinant of clinical outcome: differences between trial-participants and Every Day Clinical Care patients in the field of interventional cardiology
Journal: Int J Cardiol
Volume: 169
Issue: 4
Pages: 305-10
Date: Nov 15
Short Title: Trial participation as a determinant of clinical outcome: differences between trial-participants and Every Day Clinical Care patients in the field of interventional cardiology
Alternate Journal: International journal of cardiology
ISSN: 1874-1754 (Electronic)
0167-5273 (Linking)
DOI: 10.1016/j.ijcard.2013.09.011
Accession Number: 24144926
Abstract: BACKGROUND: This study examines differences in clinical outcome between trial-participants and non-participants after percutaneous coronary intervention (PCI). METHODS AND RESULTS: This study compromised of 11,931 consecutive patients who underwent PCI in a high volume center, during the period 2000 – 2009. Of these patients, 1787 (15%) participated in an interventional clinical trial with a follow-up period of at least six months. The maximum follow-up duration was 11.8 years, with a median of 3.8 years (IQR: 2.6 – 6.5). Baseline and procedural characteristics differed between trial-participants and non-participants. Trial-participants were more often male, were younger, had more cardiovascular risk factors and were treated more often for stable angina pectoris and single vessel disease. Overall mortality at maximum follow-up was lower for trial-participants compared to non-participants (8.1% versus 17.6%, p<0.001, adjusted HR, 0.62, 95% CI: 0.52-0.74). There was no difference in the incidence of non-fatal MI and CABG. Repeat PCI was seen more often in trial-participants (18.1% versus 30.7%, p<0.001, adjusted HR 1.91, 95%CI 1.73-2.10). Consequently, a higher incidence of the composite of mortality, repeat revascularization, and non-fatal MI was seen in the trail-participants (adjusted HR.1.36 95% CI 1.25 – 1.47), but this association was primarily driven by the occurrence of repeat PCI. CONCLUSION: Participants in clinical trials in the field of interventional cardiology with a follow-up of at least six months differed considerably from non-participants in baseline and procedural characteristics. Trial-participants had better survival than non-participants. In contrast, a two-fold higher incidence of repeat PCI was observed in trial-participants.
Notes: de Boer, Sanneke P M
van Leeuwen, Maarten A H
Cheng, Jin M
Oemrawsingh, Rohit M
van Geuns, Robert-Jan
Serruys, Patrick W J C
Boersma, Eric
Lenzen, Mattie J
eng
Netherlands
2013/10/23 06:00
Int J Cardiol. 2013 Nov 15;169(4):305-10. doi: 10.1016/j.ijcard.2013.09.011. Epub 2013 Oct 5.
URL: http://www.ncbi.nlm.nih.gov/pubmed/24144926
Author Address: Department of Cardiology, Erasmus MC, Thoraxcenter, Rotterdam, The Netherlands.

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