Cardiology 2013 (Full reference info)

Reference Type: Journal Article
Record Number: 387Author: Corno, A. F.
Year: 2013
Title: Frontiers in pediatric cardiology-specialty grand challenge
Journal: Front Pediatr
Volume: 1
Pages: 3
Short Title: Frontiers in pediatric cardiology-specialty grand challenge
Alternate Journal: Frontiers in pediatrics
ISSN: 2296-2360 (Electronic)
2296-2360 (Linking)
DOI: 10.3389/fped.2013.00003
PMCID: 3860873
Accession Number: 24400251
Notes: Corno, Antonio F
eng
Switzerland
2014/01/09 06:00
Front Pediatr. 2013 Feb 27;1:3. doi: 10.3389/fped.2013.00003. eCollection 2013.
URL: http://www.ncbi.nlm.nih.gov/pubmed/24400251
Author Address: Cardiovascular Surgery/Pediatric Cardiac Surgery, King Fahad Medical City Riyadh, Saudi Arabia.

Reference Type: Journal Article
Record Number: 801Author: Corrao, S., La Rocca, G., Lo Iacono, M., Zummo, G., Gerbino, A., Farina, F. and Anzalone, R.
Year: 2013
Title: New frontiers in regenerative medicine in cardiology: the potential of Wharton’s jelly mesenchymal stem cells
Journal: Curr Stem Cell Res Ther
Volume: 8
Issue: 1
Pages: 39-45
Date: Jan
Short Title: New frontiers in regenerative medicine in cardiology: the potential of Wharton’s jelly mesenchymal stem cells
Alternate Journal: Current stem cell research & therapy
ISSN: 1574-888X (Print)
Accession Number: 23278911
Keywords: *Cardiology
Cardiovascular Diseases/*therapy
Humans
Mesenchymal Stromal Cells/*cytology
*Regenerative Medicine
Wharton Jelly/*cytology
Abstract: Cardiomyopathies are still the first cause of death in the world. The identification of resident stem cells, comprising those derived from sub-endocardial stroma, suggests the possible self regeneration of the heart under autocrine/paracrine modulation in the cardiac microenvironment. Nevertheless, because of the limited in vivo regeneration potential of damaged cardiac tissue, the use of drugs and ultimately cardiac transplantation remain the common treatments of heart diseases and defects. The differentiative potential of embryonic and mesenchymal stem cells (MSCs) derived from different tissues (such as bone marrow and adipose tissue) was extensively explored in cell therapy for regenerative medicine. Many groups have been focused, in recent years, on isolation, characterization, and differentiation potential of MSCs derived from perinatal (or extraembryonic) tissues, mainly the placenta and the human umbilical cord. In this review, we summarized recent works about the stemness of Wharton’s jelly stromal cells and their potential in cardiac regeneration with favourable use in cell therapy and regenerative medicine. The peculiar features of these cells, as the expression of cardiac-specific transcription factors and immunomodulatory molecules suggest that human umbilical cord may be considered as a reliable alternative source of MSC useful for advanced therapy in cardiac regenerative medicine.
Notes: Corrao, Simona
La Rocca, Giampiero
Lo Iacono, Melania
Zummo, Giovanni
Gerbino, Aldo
Farina, Felicia
Anzalone, Rita
eng
Research Support, Non-U.S. Gov’t
Review
United Arab Emirates
2013/01/03 06:00
Curr Stem Cell Res Ther. 2013 Jan;8(1):39-45.
URL: http://www.ncbi.nlm.nih.gov/pubmed/23278911
Author Address: Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy.

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