Cardiology 2013 (Full reference info)
March 9, 2014
Reference Type: Journal Article
Record Number: 638Author: Chen, Y. Y., Chilipko, A. A. and Norwood, D. K.
Title: PSAP 2013, Book 1, Cardiology/Endocrinology
Journal: Ann Pharmacother
Date: May 14
Short Title: PSAP 2013, Book 1, Cardiology/Endocrinology
Alternate Journal: The Annals of pharmacotherapy
ISSN: 1542-6270 (Electronic)
Accession Number: 23673533
Notes: Chen, Ying Yin
Chilipko, Allison A
Norwood, Daryn K
Ann Pharmacother. 2013 May 14.
Author Address: Pharmacy Department, MedStar Union Memorial, Hospital, Baltimore, MD.
Reference Type: Journal Article
Record Number: 519Author: Chowdhury, F. U., Vaidyanathan, S., Bould, M., Marsh, J., Trickett, C., Dodds, K., Clark, T. P., Sapsford, R. J., Dickinson, C. J., Patel, C. N. and Thorley, P. J.
Title: Rapid-acquisition myocardial perfusion scintigraphy (MPS) on a novel gamma camera using multipinhole collimation and miniaturized cadmium-zinc-telluride (CZT) detectors: prognostic value and diagnostic accuracy in a ‘real-world’ nuclear cardiology service
Journal: Eur Heart J Cardiovasc Imaging
Short Title: Rapid-acquisition myocardial perfusion scintigraphy (MPS) on a novel gamma camera using multipinhole collimation and miniaturized cadmium-zinc-telluride (CZT) detectors: prognostic value and diagnostic accuracy in a ‘real-world’ nuclear cardiology service
Alternate Journal: European heart journal cardiovascular Imaging
ISSN: 2047-2412 (Electronic)
Accession Number: 23975570
Abstract: AIMS: To study the prognostic value of rapid-acquisition adenosine stress-rest myocardial perfusion scintigraphy (MPS) on a gamma camera using multipinhole collimation and cadmium-zinc-telluride (CZT) detectors. The secondary aim was to assess the diagnostic accuracy of the technique compared with invasive coronary angiography. METHODS AND RESULTS: Retrospective analysis of 1109 consecutive patients undergoing MPS in a routine clinical setting on a high-efficiency multipinhole gamma camera. MPS acquisition, performed with a standard injection of 550 MBq of (99m)Tc-tetrofosmin, required a mean (+/-SD) scanning time of 322 +/- 51 s. The hard cardiac event rate at a median (inter-quartile range) follow-up of 624 (552-699) days was 0.4% (95% CI 0.1-1.1) in patients with no significant perfusion abnormality versus 6.8% (95% CI 4.3-10.7%, P < 0.001) in those with an abnormal scan. In a sub-group of 165 patients, comparison with obstructive coronary artery disease on X-ray angiography gave a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for rapid-acquisition MPS of 84% (95% CI 74-91), 79% (95% CI 68-87), 82% (95% CI 72-89), 81% (95% CI 70-89), and 82% (95% CI 73-89), respectively. CONCLUSIONS: MPS performed on a CZT solid-state detector camera with multipinhole collimation is an evolutionary development that provides reliable prognostic and diagnostic information, while significantly reducing image acquisition time.
Notes: Chowdhury, F U
Clark, T P R
Sapsford, R J
Dickinson, C J
Patel, C N
Thorley, P J
Eur Heart J Cardiovasc Imaging. 2014 Mar;15(3):275-83. doi: 10.1093/ehjci/jet149. Epub 2013 Aug 23.
Author Address: Department of Clinical Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.