Cardiology 2013 (Full reference info)

Reference Type: Journal Article
Record Number: 573Author: Karamanou, M., Androutsos, G., Stefanadis, C. and Papaioannou, T. G.
Year: 2013
Title: Midas touch in cardiology
Journal: Eur Heart J
Volume: 34
Issue: 20
Pages: 1463-4
Date: May
Short Title: Midas touch in cardiology
Alternate Journal: European heart journal
ISSN: 1522-9645 (Electronic)
0195-668X (Linking)
Accession Number: 23841146
Keywords: Cardiology/*history
Gold/*history
History, 15th Century
History, 19th Century
History, 20th Century
History, 21st Century
History, Ancient
Notes: Karamanou, Marianna
Androutsos, George
Stefanadis, Christodoulos
Papaioannou, Theodore G
eng
Historical Article
Portraits
England
2013/07/11 06:00
Eur Heart J. 2013 May;34(20):1463-4.
URL: http://www.ncbi.nlm.nih.gov/pubmed/23841146
Author Address: Athens University Medical School. mkaramanou@uoa.gr

Reference Type: Journal Article
Record Number: 670Author: Kelly, A., Kennedy, A., John, B. M., Duane, B., Lemanowicz, J. and Little, J.
Year: 2013
Title: A comparison of heart rate changes associated with levalbuterol and racemic albuterol in pediatric cardiology patients
Journal: Ann Pharmacother
Volume: 47
Issue: 5
Pages: 644-50
Date: May
Short Title: A comparison of heart rate changes associated with levalbuterol and racemic albuterol in pediatric cardiology patients
Alternate Journal: The Annals of pharmacotherapy
ISSN: 1542-6270 (Electronic)
1060-0280 (Linking)
DOI: 10.1345/aph.1S003
Accession Number: 23613097
Keywords: Adolescent
Albuterol/*adverse effects/chemistry/therapeutic use
Bronchoconstriction/drug effects
Bronchodilator Agents/*adverse effects/therapeutic use
Cardiovascular Diseases/*physiopathology
Child
Child, Preschool
Dose-Response Relationship, Drug
Female
Heart Rate/*drug effects
Hospitals, Pediatric
Humans
Infant
Male
Retrospective Studies
Abstract: BACKGROUND: To our knowledge, no data exist regarding the effect of levalbuterol and racemic albuterol on heart rate in pediatric cardiology patients. OBJECTIVE: To compare heart rate change in pediatric cardiology patients receiving levalbuterol and/or racemic albuterol. The secondary objective was to identify characteristics associated with heart rate changes observed with these drugs. METHODS: A review of electronic medical records at a pediatric academic hospital was conducted to determine the equivalence of heart rate change in patients receiving levalbuterol or racemic albuterol. Patients receiving at least 3 doses of levalbuterol and/or racemic albuterol during the study period were included if they were younger than 18 years and had a diagnosis of congenital heart disease (CHD), cardiomyopathy, or supraventricular tachycardia. Patients were excluded if they received a beta-blocker or continuous racemic albuterol or did not have documented pre- and postdose heart rates. RESULTS: One hundred ninety-two patients were included. One hundred forty-two received racemic albuterol, 40 received levalbuterol, and 10 received both racemic albuterol and levalbuterol. The mean increase in heart rate for patients receiving racemic albuterol and levalbuterol was 6.8 beats/min and 6.2 beats/min, respectively (p = 0.01). In patients with CHD, the racemic albuterol group experienced a mean heart rate increase of 6.6 beats/min compared to 6.3 beats/min in the levalbuterol group (p = 0.01). Equivalence was also determined in patients without surgical intervention and patients receiving concomitant cardiac and respiratory medications. Equivalence was not established in other analyzed subgroups secondary to insufficient sample sizes. CONCLUSIONS: Racemic albuterol and levalbuterol were associated with increased heart rate in pediatric cardiology patients. This increase was found to be equivalent.
Notes: Kelly, Anne
Kennedy, Audrey
John, Barnabas M
Duane, Blythe
Lemanowicz, Jack
Little, Jeff
eng
Comparative Study
2013/04/25 06:00
Ann Pharmacother. 2013 May;47(5):644-50. doi: 10.1345/aph.1S003. Epub 2013 Apr 23.
URL: http://www.ncbi.nlm.nih.gov/pubmed/23613097
Author Address: Department of Pharmacy, Children’s Mercy Hospitals and Clinics, Kansas City, MO, USA. amkelly@cmh.edu

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