Cardiology 2013 (Full reference info)

Reference Type: Journal Article
Record Number: 499Author: Huffman, J. C., Beach, S. R., Suarez, L., Mastromauro, C. A., DuBois, C. M., Celano, C. M., Rollman, B. L. and Januzzi, J. L.
Year: 2013
Title: Design and baseline data from the Management of Sadness and Anxiety in Cardiology (MOSAIC) randomized controlled trial
Journal: Contemp Clin Trials
Volume: 36
Issue: 2
Pages: 488-501
Date: Nov
Short Title: Design and baseline data from the Management of Sadness and Anxiety in Cardiology (MOSAIC) randomized controlled trial
Alternate Journal: Contemporary clinical trials
ISSN: 1559-2030 (Electronic)
1551-7144 (Linking)
DOI: 10.1016/j.cct.2013.09.012
Accession Number: 24090821
Abstract: BACKGROUND: Depression and anxiety in cardiac patients are independently associated with adverse cardiovascular outcomes, including mortality. Collaborative care (CC) programs, which use care managers to assess patients, coordinate care, and perform therapeutic interventions, have proven effective in managing depression in this population. However, no prior CC intervention has simultaneously managed depression and anxiety disorders, and there has been minimal study of CC in high-risk cardiac inpatients. MATERIALS AND METHODS: The Management of Sadness and Anxiety in Cardiology (MOSAIC) study was a prospective randomized trial of a low-intensity CC intervention, compared to enhanced usual care, for patients hospitalized for acute coronary syndrome, heart failure, or arrhythmia, and diagnosed with depression, generalized anxiety disorder (GAD), or panic disorder (PD). The primary outcome measure for MOSAIC was mental health-related quality of life (HRQoL), measured using the Medical Outcomes Study Short Form-12. Additional outcomes included psychological, functional, and medical outcomes, including rehospitalizations. RESULTS: A total of 183 eligible participants were enrolled (92 collaborative care, 91 enhanced usual care); 94% of depressed patients reported being depressed for >1month, and 53% of those with GAD reported clinically significant anxiety for >1year. One hundred thirty-three patients had depression, 118 had GAD, and 19 had PD; 74 participants (40%) had two or more of the disorders. CONCLUSION: The MOSAIC trial will provide data regarding whether an intervention that concurrently manages these common psychiatric disorders results in meaningful improvements in HRQoL, psychiatric symptoms, and medical outcomes in cardiac patients at high risk for adverse outcomes.
Notes: Huffman, Jeff C
Beach, Scott R
Suarez, Laura
Mastromauro, Carol A
DuBois, Christina M
Celano, Christopher M
Rollman, Bruce L
Januzzi, James L
eng
2013/10/05 06:00
Contemp Clin Trials. 2013 Nov;36(2):488-501. doi: 10.1016/j.cct.2013.09.012. Epub 2013 Oct 1.
URL: http://www.ncbi.nlm.nih.gov/pubmed/24090821
Author Address: Harvard Medical School, Boston, MA, United States; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States. Electronic address: jhuffman@partners.org.

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155