Cardiology 2013. Part II.

Notes: Smith, Fay

Lambert, Trevor W

Pitcher, Alex

Goldacre, Michael J

eng

Research Support, Non-U.S. Gov’t

England

2013/01/29 06:00

BMC Med Educ. 2013 Jan 25;13:10. doi: 10.1186/1472-6920-13-10.

URL: http://www.ncbi.nlm.nih.gov/pubmed/23351301

Author Address: UK Medical Careers Research Group, Department of Public Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.

 

 

Reference Type:  Journal Article

Record Number: 965Author: Snyder, C. S. and Moodie, D.

Year: 2013

Title: The American Academy of Pediatrics Section on Cardiology Meeting

Journal: Congenit Heart Dis

Volume: 8

Issue: 2

Pages: 178-80

Date: Mar-Apr

Short Title: The American Academy of Pediatrics Section on Cardiology Meeting

Alternate Journal: Congenital heart disease

ISSN: 1747-0803 (Electronic)

1747-079X (Linking)

DOI: 10.1111/chd.12052

Accession Number: 23480309

Keywords: *Biomedical Research

*Cardiology

Humans

*Pediatrics

Societies, Medical

Notes: Snyder, Christopher S

Moodie, Douglas

eng

Congresses

2013/03/14 06:00

Congenit Heart Dis. 2013 Mar-Apr;8(2):178-80. doi: 10.1111/chd.12052. Epub 2013 Mar 11.

URL: http://www.ncbi.nlm.nih.gov/pubmed/23480309

Author Address: Case Western Reserve University School of Medicine, Rainbow Babies & Children’s Hospital, Cleveland, OH 44120, USA.

 

 

Reference Type:  Journal Article

Record Number: 1001Author: Spira, M. E. and Hai, A.

Year: 2013

Title: Multi-electrode array technologies for neuroscience and cardiology

Journal: Nat Nanotechnol

Volume: 8

Issue: 2

Pages: 83-94

Date: Feb

Short Title: Multi-electrode array technologies for neuroscience and cardiology

Alternate Journal: Nature nanotechnology

ISSN: 1748-3395 (Electronic)

1748-3387 (Linking)

DOI: 10.1038/nnano.2012.265

Accession Number: 23380931

Keywords: Action Potentials/physiology

Bioengineering

Cardiology/*methods

Electrophysiological Phenomena

Humans

Microarray Analysis

*Microelectrodes

Nanomedicine/methods

Neurons/physiology

Neurosciences/*methods

Patch-Clamp Techniques

Abstract: At present, the prime methodology for studying neuronal circuit-connectivity, physiology and pathology under in vitro or in vivo conditions is by using substrate-integrated microelectrode arrays. Although this methodology permits simultaneous, cell-non-invasive, long-term recordings of extracellular field potentials generated by action potentials, it is ‘blind’ to subthreshold synaptic potentials generated by single cells. On the other hand, intracellular recordings of the full electrophysiological repertoire (subthreshold synaptic potentials, membrane oscillations and action potentials) are, at present, obtained only by sharp or patch microelectrodes. These, however, are limited to single cells at a time and for short durations. Recently a number of laboratories began to merge the advantages of extracellular microelectrode arrays and intracellular microelectrodes. This Review describes the novel approaches, identifying their strengths and limitations from the point of view of the end users–with the intention to help steer the bioengineering efforts towards the needs of brain-circuit research.

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