Cardiology 2013

Notes: Connolly, Michael

Menown, Ian B A

eng

Review

2013/04/13 06:00

Adv Ther. 2013 Apr;30(4):369-86. doi: 10.1007/s12325-013-0024-5. Epub 2013 Apr 9.

URL: http://www.ncbi.nlm.nih.gov/pubmed/23579862

Author Address: Craigavon Cardiac Centre, Craigavon Hospital, Southern Trust, Northern Ireland, BT63 5QQ, UK.

 

 

Reference Type:  Journal Article

Record Number: 387Author: Corno, A. F.

Year: 2013

Title: Frontiers in pediatric cardiology-specialty grand challenge

Journal: Front Pediatr

Volume: 1

Pages: 3

Short Title: Frontiers in pediatric cardiology-specialty grand challenge

Alternate Journal: Frontiers in pediatrics

ISSN: 2296-2360 (Electronic)

2296-2360 (Linking)

DOI: 10.3389/fped.2013.00003

PMCID: 3860873

Accession Number: 24400251

Notes: Corno, Antonio F

eng

Switzerland

2014/01/09 06:00

Front Pediatr. 2013 Feb 27;1:3. doi: 10.3389/fped.2013.00003. eCollection 2013.

URL: http://www.ncbi.nlm.nih.gov/pubmed/24400251

Author Address: Cardiovascular Surgery/Pediatric Cardiac Surgery, King Fahad Medical City Riyadh, Saudi Arabia.

 

 

Reference Type:  Journal Article

Record Number: 801Author: Corrao, S., La Rocca, G., Lo Iacono, M., Zummo, G., Gerbino, A., Farina, F. and Anzalone, R.

Year: 2013

Title: New frontiers in regenerative medicine in cardiology: the potential of Wharton’s jelly mesenchymal stem cells

Journal: Curr Stem Cell Res Ther

Volume: 8

Issue: 1

Pages: 39-45

Date: Jan

Short Title: New frontiers in regenerative medicine in cardiology: the potential of Wharton’s jelly mesenchymal stem cells

Alternate Journal: Current stem cell research & therapy

ISSN: 1574-888X (Print)

Accession Number: 23278911

Keywords: *Cardiology

Cardiovascular Diseases/*therapy

Humans

Mesenchymal Stromal Cells/*cytology

*Regenerative Medicine

Wharton Jelly/*cytology

Abstract: Cardiomyopathies are still the first cause of death in the world. The identification of resident stem cells, comprising those derived from sub-endocardial stroma, suggests the possible self regeneration of the heart under autocrine/paracrine modulation in the cardiac microenvironment. Nevertheless, because of the limited in vivo regeneration potential of damaged cardiac tissue, the use of drugs and ultimately cardiac transplantation remain the common treatments of heart diseases and defects. The differentiative potential of embryonic and mesenchymal stem cells (MSCs) derived from different tissues (such as bone marrow and adipose tissue) was extensively explored in cell therapy for regenerative medicine. Many groups have been focused, in recent years, on isolation, characterization, and differentiation potential of MSCs derived from perinatal (or extraembryonic) tissues, mainly the placenta and the human umbilical cord. In this review, we summarized recent works about the stemness of Wharton’s jelly stromal cells and their potential in cardiac regeneration with favourable use in cell therapy and regenerative medicine. The peculiar features of these cells, as the expression of cardiac-specific transcription factors and immunomodulatory molecules suggest that human umbilical cord may be considered as a reliable alternative source of MSC useful for advanced therapy in cardiac regenerative medicine.

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